منابع مشابه
A theoretical compartment model for antigen kinetics in the skin.
The skin is a promising location for vaccination with its abundant population of antigen capturing and presenting cells. The development of new techniques, such as the use of microneedles, can facilitate the delivery of vaccines into the skin. In recent years, many different types of microneedle arrays have been designed. However, their geometry and arrangement within an array may be optimized ...
متن کاملOne hundred years of Michaelis–Menten kinetics
0.1016/j.pisc.2014 he Author. Publish mons.org/licenses t of an special issu etics”. Copyright thor. [email protected] Abstract The year 2013 marked the centenary of the paper of Leonor Michaelis and Maud Menten (Michaelis and Menten, 1913), and the 110th anniversary of the doctoral thesis of Victor Henri (Henri, 1903). These publications have had an enormous influence on the progress of biochem...
متن کاملThree-compartment (3C) pharmacokinetic modeling is more accurate than two-compartment (2C) modeling of myocardial fibrosis gadolinium kinetics
We observed significantly different curve shapes in healed chronic myocardial infarction when compared with normal myocardium and found that gadolinium kinetics was more accurately modeled (greater R2) with a 3C model rather than a 2C model. 2C Modeling of fibrotic and normal myocardium showed both a significant difference between the transport into the tissue and extracellular volumes while 3C...
متن کاملStudies of skeletal tracer kinetics: II. evaluation of a five-compartment model of [18F]fluoride kinetics in rats.
We have evaluated a five-compartment model of [18F]fluoride kinetics in rats. The initial fluoride distribution was found to be similar to that of [77Br]bromide, a known extracellular-fluid (ECF) tracer, in agreement with the hypothesis underlying the model, and the measured uptake rate in rat bones compared well with the digital computer solution. Simpler models did not give a better fit. In d...
متن کاملOn Single Compartment Pharmacokinetic Model Systems that Obey Michaelis-Menten Kinetics and Systems that Obey Krebs Cycle Kinetics
The integration of Michaelis-Menten kinetics results in a trancedental equation. The results are not in a form that is readily usable. A more usable form of the model solutions is developed. This was accomplished by using Taylor series expansion of dimensionless concentration u in terms of its derivatives. The infinite series expression for dimensionless concentration is given. It can be seen t...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1992
ISSN: 0007-0912
DOI: 10.1093/bja/69.4.387